Shortly after the half time whistle, paramedics were called into the changing room before taking Clarke to Queens Medical Centre in Nottingham.
Tim Davies, Leicester City's chief executive said: "He was taken away in an ambulance to hospital. He did offer a few words in the ambulance. Our thoughts and prayers are with Clive and his family."
The Nottingham Forest chief executive added: "I think football is secondary to human issues."
Nottingham Forest had been leading 1-0 at the time after a goal from Junior Agogo, however after a 15 minute delay both managers agreed to abandon the game as many of the players had been shaken up by the incident.
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