International team of scientists studies malaria drug resistance in Southeast Asia
Saturday, August 2, 2014
Researchers from, , , and the have mapped resistance of -causing parasite to antimalarial drug , mainly in ; correlated the resistance-causing mutation with slow parasite ; and found that prolonged therapy is highly effective against drug-resistant malaria. Their study was published in on Thursday.
The mutation considered in this study was identified last year as theof artemisinin-resistant malaria. The current study found the mutation, located in the of a on , predicted when parasite clearance would exceed five hours with — usually correct in predicting both when long half-life would occur, and when it wouldn't. web-based database was used for collection of data which was used to assess parasite clearance rate.
The study found a six-day treatment course effective against artemisinin-resistant malaria. The standard regimen consists of three-day– treatment, and had a 25% rate of failure at day 42 in another recent study in , . The prolonged regimen which includes three days of followed by three days of dihydroartemisinin–piperaquine, has shown 2% rate of failure at day 42 in the same area. of the half-life values were similar in two treatment groups of 60 patients each at each study site: one group received at a daily dose of 2 per patient's body-weight and the other 4 mg per kilogram. Afterwards, patients at several study sites were followed for 42 days — Pailin, Cambodia; , ; , ; Shwe Kyin, ; and Pingilikani, — and for 28 days in , . The treatment regimens were highly effective at all the study sites.
Support for the study came from the, the Worldwide Antimalarial Resistance Network, the of the of the , and the . Also, the UK-based funds one of the participating research organizations, the – Tropical Medicine Research Programme.
- Ashley, Elizabeth A. Ashley et al.. "Spread of Artemisinin Resistance in Plasmodium falciparum Malaria" — July 31, 2014
- Jennifer Routh (Resistance to key malaria drug spreading at alarming rate in Southeast Asia" — , July 30, 2014